منابع مشابه
Retinoid receptors and keratinocytes.
In 1987, a tremendous boost in our understanding of the action of dietary vitamin A occurred with the discovery and characterization of nuclear receptors for retinoic acid, the active form of the vitamin, in the laboratories of P. Chambon and R. Evans. They have shown that the nuclear receptors are ligand-activated transcription factors capable of specific gene regulation. Since that discovery,...
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates the expression of LDL receptor (LDLR) protein. Gain-of-function mutations in PCSK9 cause hypercholesterolemia, and loss-of-function mutations result in lower plasma LDL-cholesterol. Here, we investigate the kinetics and metabolism of circulating PCSK9 relative to tissue levels of LDLRs. The administration...
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Versican-like proteoglycans are the main component of the intimal extracellular matrix interacting with low density lipoprotein (LDL). The aim of this study has been to investigate the receptors involved in versican-modified LDL uptake by human vascular smooth muscle cells (VSMCs). We have found that versican-LDL interaction leads to the following: (1) monomeric LDL particles that are similar i...
متن کاملRole of LDL receptors in the in vitro uptake and degradation of LDL in the media of rabbit thoracic aorta.
The possible role of plasma low-density protein (LDL) receptors in the uptake and degradation of LDL in the whole arterial wall was investigated by comparison of the in vitro uptake of 125I-native LDL (nLDL) and 131I-methylated LDL (mLDL) by the media of deendothelialized rabbit thoracic aorta excised at in vivo length and pressurized to 70 mm Hg, taking the advantage that mLDL is not recognize...
متن کاملLDL, Scavenger, and B-VLDL Receptors on Aortic Endothelial Cells
Primary and first passage aortic endothelial cells were shown to possess a high affinity receptor for B-mlgrating very low density lipoproteins (B-VLDL) distinct from the low density lipoprotein (LDL) receptor and scavenger receptor on these cells. In bovine aortic endothelial cells, l-rabbit B-VLDL was taken up and degraded by a high affinity process that was competed for by uniabeled rabbit R...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1992
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12462204